1774-P: Verapamil Prevents Decline of IGF-1 in Subjects with T1D

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Authors: XU, GUANLAN, CHEN, JUNQIN, LU, BRIAN, QIAN, WEIJUN, SHALEV, ANATH
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20.06.2023
• Subjects: Antihypertensives; Apoptosis; Beta cells; Cell differentiation; Cell growth; Diabetes mellitus (insulin dependent); Diagnosis; Enzyme-linked immunosorbent assay; Glucose metabolism; Homeostasis; Immunomodulation; Insulin-like growth factor I; Insulin-like growth factors; Liquid chromatography; Mass spectroscopy; Monocytes; Peripheral blood; Placebos; Proteomics; Serum levels; Verapamil

We have previously found that the calcium channel blocker and anti-hypertensive, verapamil, promotes functional beta cell mass and improves glucose homeostasis in diabetic mice and in humans with recent-onset type 1 diabetes (T1D). Surprisingly, we also discovered that verapamil reversed the T1D-ass...