Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects

• Published in: Biological psychiatry (1969) Vol. 70; no. 7; pp. 663 - 671
• Main Authors: Miller, Brian J., Buckley, Peter, Seabolt, Wesley, Mellor, Andrew, Kirkpatrick, Brian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2011
• Subjects: Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Cytokines; Cytokines - blood; Cytokines - cerebrospinal fluid; Cytokines - drug effects; first-episode psychosis; Humans; Interleukin 1 Receptor Antagonist Protein - blood; Interleukin 1 Receptor Antagonist Protein - cerebrospinal fluid; Interleukin 1 Receptor Antagonist Protein - drug effects; meta-analysis; Psychiatry; Receptors, Cytokine - blood; Receptors, Cytokine - drug effects; Recurrence; relapse; schizophrenia; Schizophrenia - blood; Schizophrenia - cerebrospinal fluid; Schizophrenia - diagnosis; Schizophrenia - drug therapy; meta-analysis; schizophrenia; Cytokines; relapse; first-episode psychosis

Schizophrenia is associated with immune system dysfunction, including aberrant cytokine levels. We performed a meta-analysis of these associations, considering effects of clinical status and antipsychotic treatment following an acute illness exacerbation. We identified articles by searching PubMed,...