Effect of Matrix Metallopeptidase 13 on the Function of Mouse Bone Marrow-derived Dendritic Cells

• Published in: Chinese medical journal Vol. 130; no. 6; pp. 717 - 721
• Main Authors: Li, Xiao-Dong, Zhang, Xin-Rui, Li, Zhi-Hao, Yang, Yang, Zhang, Duo, Zheng, Heng, Dong, Shu-Ying, Chen, Juan, Zeng, Xian-Dong
• Format: Journal Article
• Language: English
• Published: China Medknow Publications and Media Pvt. Ltd 20.03.2017; Lippincott Williams & Wilkins Ovid Technologies; Department of Dermatology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, China%Department of Dermatology Key Laboratory of Immunodermatology, No.1 Hospital of China Medical University, Shenyang, Liaoning 110001, China%Department of Oncology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Apoptosis; Dendritic Cell; Matrix Metallopeptidase 13; Maturation; Phagocytosis; Bone marrow; Bone Marrow Cells - cytology; DCS控制系统; Dendritic cells; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - metabolism; Dermatology; Experiments; Female; Flow cytometry; Gene expression; Health aspects; Hospitals; Immunoglobulins; Inflammation; Lipopolysaccharides - pharmacology; Matrix Metalloproteinase 13 - metabolism; Matrix Metalloproteinase 13 - physiology; Matrix metalloproteinase inhibitors; Medical research; Mice; Mice, Inbred C57BL; Original; Polymerase chain reaction; Proteins; RNA, Small Interfering; Western印迹法; 凋亡相关基因; 基质金属蛋白酶; 小鼠骨髓; 抗原呈递细胞; 树突状细胞; 细胞功能; United States > US; Matrix Metallopeptidase 13; Maturation; Phagocytosis; Dendritic Cell; Apoptosis

Background： Dendritic cells are professional antigen-presenting cells found in an immature state in epithelia and interstitial space, where they capture antigens such as pathogens or damaged tissue. Matrix metallopeptidase 13 （MMP- 13）, a member of the collagenase subfamily, is involved in many diff...