A novel function of IL-2: Chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation

• Published in: Journal of autoimmunity Vol. 38; no. 4; pp. 322 - 331
• Main Authors: Sharma, Rahul, Sung, Sun-Sang J., Gaskin, Felicia, Fu, Shu Man, Ju, Shyr-Te
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2012; Elsevier
• Subjects: Allergy and Immunology; Animals; Antigens, CD - genetics; Antigens, CD - physiology; Biological and medical sciences; CD4 antigen; Chemokine CX3CL1 - genetics; Chemokine CX3CL1 - physiology; Chemokines; Chemotactic factors; Cytokine; Dermatitis - genetics; Dermatitis - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; gamma -Interferon; Helper cells; Immunoglobulin E - immunology; Inflammation; Integrin alpha Chains - genetics; Integrin alpha Chains - physiology; Interferon-gamma - genetics; Interferon-gamma - metabolism; Interleukin 1; Interleukin 13; Interleukin 2; Interleukin 4; Interleukin 5; Interleukin-10 - genetics; Interleukin-10 - physiology; Interleukin-2 - genetics; Interleukin-2 - physiology; Interleukin-4 - genetics; Interleukin-4 - immunology; Lung; Lymphocytes T; Mice; Mice, Knockout; Pneumonia - genetics; Pneumonia - immunology; Receptor mechanisms; Receptors, Chemokine - genetics; Receptors, Chemokine - physiology; Receptors, Leukotriene B4 - genetics; Receptors, Leukotriene B4 - physiology; Regulatory T-cell; Skin; Skin and lung inflammation; Stat6 protein; STAT6 Transcription Factor - genetics; STAT6 Transcription Factor - physiology; T-Lymphocytes, Helper-Inducer - drug effects; T-Lymphocytes, Helper-Inducer - immunology; Th17 Cells - immunology; Th17 Cells - metabolism; Th2 Cells - immunology; Th2 Cells - metabolism; Trafficking receptor gene; Regulatory T-cell; Skin and lung inflammation; Cytokine; Trafficking receptor gene; Induction; Lung; Inflammation; Chemokine receptor; Retention; Respiratory system; Chemotaxis; Immunology; Gene; Interleukin 2; T-Lymphocyte; Genetics; Skin; Regulatory cell; Biological receptor

The Foxp3+CD4+ regulatory T-cell (Treg)-deficient Scurfy (Sf) mice rapidly develop severe inflammation in the skin and lungs with expanded Th subsets bearing increased expression of various chemokine/chemoattractant/retention receptor genes (CRG). Nine different double mutants were generated to eluc...