Echocardiographic Evaluation of Coronary Abnormalities and Cardiac Function in a Murine Model of Kawasaki Disease Using High-frequency Ultrasound
Background： Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease （KD）. This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound syst...
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| Published in | Chinese medical journal Vol. 130; no. 12; pp. 1467 - 1474 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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China
Medknow Publications and Media Pvt. Ltd
20.06.2017
Lippincott Williams & Wilkins Ovid Technologies Department of Cardiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China Key Laboratory of Major Disease in Children, Ministry of Health, Beijing 100045, China%Pediatric Cardiac Intensive Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China%Chinese Academy of Medical Sciences and Comparative Medical Center, Beijing 100021, China Medknow Publications & Media Pvt Ltd Wolters Kluwer |
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| Online Access | Get full text |
| ISSN | 0366-6999 2542-5641 2542-5641 |
| DOI | 10.4103/0366-6999.207461 |
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| Abstract | Background： Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease （KD）. This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD. Methods： Lactobacillus case~ cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally （i.p.） to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin （IVIG） treatment group was i.p. injected with IVIG （2 g/kg）, while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 （high-resolution small animal ultrasound [Vevo770 pattem; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]） which were measured and analyzed with Vevo770 software. Results： Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group （0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ±0.05 mm; 0.34±0.04 mm） was significantly larger than those of 1VIG treatment group （0.22± 0.02 mm; 0.28 ± 0.03 mm; 0.26± 0.03 mm; 0.27 ±0.05 mm; 0.26 ± 0.03 mm; all P〈 0.01） and the normal control group （0.21 ±0.02 mm; 0.22 ±0.03 mm; 0.22± 0.02 mm; 0.23 ± 0.02 mm; 0.27± 0.04 mm; all P 〈 0.01） on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac fimction among the groups on days 0, 7, 14, 28, and 56 （all P〉 0.05）. Conclusions： Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. |
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| AbstractList | Background: Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD. Methods: Lactobacillus casei cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally (i.p.) to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin (IVIG) treatment group was i.p. injected with IVIG (2 g/kg), while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 (high-resolution small animal ultrasound [Vevo770 pattern; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]) which were measured and analyzed with Vevo770 software. Results: Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group (0.53 +- 0.09 mm; 0.36 +- 0.07 mm; 0.34 +- 0.05 mm; 0.34 +- 0.04 mm) was significantly larger than those of IVIG treatment group (0.22 +- 0.02 mm; 0.28 +- 0.03 mm; 0.26 +- 0.03 mm; 0.27 +- 0.05 mm; 0.26 +- 0.03 mm; all P < 0.01) and the normal control group (0.21 +- 0.02 mm; 0.22 +- 0.03 mm; 0.22 +- 0.02 mm; 0.23 +- 0.02 mm; 0.27 +- 0.04 mm; all P< 0.01) on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac function among the groups on days 0, 7, 14, 28, and 56 (all P > 0.05). Conclusions: Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. Background:Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD).This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD.Methods:Lactobacillus casei cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally (i.p.) to induce KD.A total of 120 mice were grouped into three groups.The intravenous immunoglobulin (IVIG) treatment group was i.p.injected with IVIG (2 g/kg),while the KD model and normal control groups were i.p.injected with 0.5 ml of phosphate buffered solution on day 5.All high-resolution echocardiography detection of mouse heart was performed by the same senior technician.Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0,7,14,28,and 56 (high-resolution small animal ultrasound [Vevo770 pattern;VisualSonic,Canada] with broadband probe [RMVTM707B;frequency,30 mHz;depth of focus,1.2 cm]) which were measured and analyzed with Vevo770 software.Results:Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group.Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects.The KD model and IVIG treatment groups showed left coronary artery dilation on days 7,14,28,and 56.The diameter of left coronary artery in the KD model group (0.53 4 0.09 mm;0.36 ± 0.07 mm;0.34 ± 0.05 mm;0.34 ± 0.04 mm) was significantly larger than those of IVIG treatment group (0.22 ± 0.02 mm;0.28 ± 0.03 mm;0.26 ± 0.03 mm;0.27 ± 0.05 mm;0.26 ± 0.03 mm;all P ＜ 0.01) and the normal control group (0.21 ± 0.02 mm;0.22 ± 0.03 mm;0.22 ± 0.02 mm;0.23 ± 0.02 mm;0.27 ± 0.04 mm;all P ＜ 0.01) on days 7,14,28,and 56.No significant differences were observed in the measurements of cardiac function among the groups on days 0,7,14,28,and 56 (all P ＞ 0.05).Conclusions:Echocardiography could identify the consecutive changes of coronary artery in KD mice.Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD.BACKGROUNDMurine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD.Lactobacillus casei cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally (i.p.) to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin (IVIG) treatment group was i.p. injected with IVIG (2 g/kg), while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 (high-resolution small animal ultrasound [Vevo770 pattern; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]) which were measured and analyzed with Vevo770 software.METHODSLactobacillus casei cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally (i.p.) to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin (IVIG) treatment group was i.p. injected with IVIG (2 g/kg), while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 (high-resolution small animal ultrasound [Vevo770 pattern; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]) which were measured and analyzed with Vevo770 software.Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group (0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ± 0.05 mm; 0.34 ± 0.04 mm) was significantly larger than those of IVIG treatment group (0.22 ± 0.02 mm; 0.28 ± 0.03 mm; 0.26 ± 0.03 mm; 0.27 ± 0.05 mm; 0.26 ± 0.03 mm; all P < 0.01) and the normal control group (0.21 ± 0.02 mm; 0.22 ± 0.03 mm; 0.22 ± 0.02 mm; 0.23 ± 0.02 mm; 0.27 ± 0.04 mm; all P< 0.01) on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac function among the groups on days 0, 7, 14, 28, and 56 (all P > 0.05).RESULTSPathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group (0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ± 0.05 mm; 0.34 ± 0.04 mm) was significantly larger than those of IVIG treatment group (0.22 ± 0.02 mm; 0.28 ± 0.03 mm; 0.26 ± 0.03 mm; 0.27 ± 0.05 mm; 0.26 ± 0.03 mm; all P < 0.01) and the normal control group (0.21 ± 0.02 mm; 0.22 ± 0.03 mm; 0.22 ± 0.02 mm; 0.23 ± 0.02 mm; 0.27 ± 0.04 mm; all P< 0.01) on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac function among the groups on days 0, 7, 14, 28, and 56 (all P > 0.05).Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model.CONCLUSIONSEchocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. Background： Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease （KD）. This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD. Methods： Lactobacillus case~ cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally （i.p.） to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin （IVIG） treatment group was i.p. injected with IVIG （2 g/kg）, while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 （high-resolution small animal ultrasound [Vevo770 pattem; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]） which were measured and analyzed with Vevo770 software. Results： Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group （0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ±0.05 mm; 0.34±0.04 mm） was significantly larger than those of 1VIG treatment group （0.22± 0.02 mm; 0.28 ± 0.03 mm; 0.26± 0.03 mm; 0.27 ±0.05 mm; 0.26 ± 0.03 mm; all P〈 0.01） and the normal control group （0.21 ±0.02 mm; 0.22 ±0.03 mm; 0.22± 0.02 mm; 0.23 ± 0.02 mm; 0.27± 0.04 mm; all P 〈 0.01） on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac fimction among the groups on days 0, 7, 14, 28, and 56 （all P〉 0.05）. Conclusions： Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. Background: Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD. Methods: Lactobacillus casei cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally (i.p.) to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin (IVIG) treatment group was i.p. injected with IVIG (2 g/kg), while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 (high-resolution small animal ultrasound [Vevo770 pattern; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]) which were measured and analyzed with Vevo770 software. Results: Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group (0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ± 0.05 mm; 0.34 ± 0.04 mm) was significantly larger than those of IVIG treatment group (0.22 ± 0.02 mm; 0.28 ± 0.03 mm; 0.26 ± 0.03 mm; 0.27 ± 0.05 mm; 0.26 ± 0.03 mm; all P < 0.01) and the normal control group (0.21 ± 0.02 mm; 0.22 ± 0.03 mm; 0.22 ± 0.02 mm; 0.23 ± 0.02 mm; 0.27 ± 0.04 mm; all P< 0.01) on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac function among the groups on days 0, 7, 14, 28, and 56 (all P > 0.05). Conclusions: Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD. Lactobacillus casei cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally (i.p.) to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin (IVIG) treatment group was i.p. injected with IVIG (2 g/kg), while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 (high-resolution small animal ultrasound [Vevo770 pattern; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]) which were measured and analyzed with Vevo770 software. Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group (0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ± 0.05 mm; 0.34 ± 0.04 mm) was significantly larger than those of IVIG treatment group (0.22 ± 0.02 mm; 0.28 ± 0.03 mm; 0.26 ± 0.03 mm; 0.27 ± 0.05 mm; 0.26 ± 0.03 mm; all P < 0.01) and the normal control group (0.21 ± 0.02 mm; 0.22 ± 0.03 mm; 0.22 ± 0.02 mm; 0.23 ± 0.02 mm; 0.27 ± 0.04 mm; all P< 0.01) on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac function among the groups on days 0, 7, 14, 28, and 56 (all P > 0.05). Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. |
| Audience | Academic |
| Author | Xin-Xin Zhang Zhong-Dong Du Shang-GuanWen Xiu-Ping Sun |
| AuthorAffiliation | Department of Cardiology, Beijing Children＇s Hospital, Capital Medical University, Beijing 100045, China Key Laboratory of Major Disease in Children, Ministry of Health, Beijing 100045, China pediatric Cardiac Intensive Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Chinese Academy of Medical Sciences and Comparative Medical Center, Beijing 100021, China |
| AuthorAffiliation_xml | – name: Department of Cardiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China;Key Laboratory of Major Disease in Children, Ministry of Health, Beijing 100045, China%Pediatric Cardiac Intensive Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China%Chinese Academy of Medical Sciences and Comparative Medical Center, Beijing 100021, China – name: 4 Chinese Academy of Medical Sciences and Comparative Medical Center, Beijing 100021, China – name: 1 Department of Cardiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China – name: 2 Key Laboratory of Major Disease in Children, Ministry of Health, Beijing 100045, China – name: 3 Pediatric Cardiac Intensive Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China |
| Author_xml | – sequence: 1 givenname: Xin-Xin surname: Zhang fullname: Zhang, Xin-Xin – sequence: 2 givenname: Zhong-Dong surname: Du fullname: Du, Zhong-Dong – sequence: 3 givenname: Shang-Guan surname: Wen fullname: Wen, Shang-Guan – sequence: 4 givenname: Xiu-Ping surname: Sun fullname: Sun, Xiu-Ping |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28584211$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_diagnostics14020145 |
| Cites_doi | 10.1056/NEJMp068268 10.1191/0961203304lu517rr 10.1097/01.mop.0000187190.97166.83 10.1097/INF.0000000000000914 10.1097/01.bor.0000197999.58073.2e 10.1067/mje.2002.117560 10.1097/01.inf.0000261196.79223.18 10.4103/0366-6999.179801 10.1002/art.1780280609 10.1093/intimm/dxg007 10.1161/01.CIR.0000145143.19711.78 |
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| Copyright | COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd. Copyright Medknow Publications & Media Pvt. Ltd. Jun 20, 2017 Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright: © 2017 Chinese Medical Journal 2017 |
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| Issue | 12 |
| Keywords | Disease Model Echocardiography Kawasaki Disease Murine |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
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| Notes | Disease Model; Echocardiography; Kawasaki Disease; Murine 11-2154/R Background： Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease （KD）. This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine model of KD with a high-frequency ultrasound system and to provide evidence for the preparation of the model of KD. Methods： Lactobacillus case~ cell wall extract was prepared and injected into C57BL/6 mice intraperitoneally （i.p.） to induce KD. A total of 120 mice were grouped into three groups. The intravenous immunoglobulin （IVIG） treatment group was i.p. injected with IVIG （2 g/kg）, while the KD model and normal control groups were i.p. injected with 0.5 ml of phosphate buffered solution on day 5. All high-resolution echocardiography detection of mouse heart was performed by the same senior technician. Animal echocardiography was performed by measuring the coronary artery dimensions and cardiac function on days 0, 7, 14, 28, and 56 （high-resolution small animal ultrasound [Vevo770 pattem; VisualSonic, Canada] with broadband probe [RMVTM707B; frequency, 30 mHz; depth of focus, 1.2 cm]） which were measured and analyzed with Vevo770 software. Results： Pathological studies revealed focal inflammatory infiltrate asymmetrically distributed around the coronary artery trunk in the KD model group. Echocardiographic study including coronary dimension and cardiac function measurements was successfully performed in all subjects. The KD model and IVIG treatment groups showed left coronary artery dilation on days 7, 14, 28, and 56. The diameter of left coronary artery in the KD model group （0.53 ± 0.09 mm; 0.36 ± 0.07 mm; 0.34 ±0.05 mm; 0.34±0.04 mm） was significantly larger than those of 1VIG treatment group （0.22± 0.02 mm; 0.28 ± 0.03 mm; 0.26± 0.03 mm; 0.27 ±0.05 mm; 0.26 ± 0.03 mm; all P〈 0.01） and the normal control group （0.21 ±0.02 mm; 0.22 ±0.03 mm; 0.22± 0.02 mm; 0.23 ± 0.02 mm; 0.27± 0.04 mm; all P 〈 0.01） on days 7, 14, 28, and 56. No significant differences were observed in the measurements of cardiac fimction among the groups on days 0, 7, 14, 28, and 56 （all P〉 0.05）. Conclusions： Echocardiography could identify the consecutive changes of coronary artery in KD mice. Echocardiography is more convenient and direct in evaluating the coronary abnormalities in this animal model. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| PublicationDate | 2017-06-20 |
| PublicationDateYYYYMMDD | 2017-06-20 |
| PublicationDate_xml | – month: 06 year: 2017 text: 2017-06-20 day: 20 |
| PublicationDecade | 2010 |
| PublicationPlace | China |
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| PublicationTitle | Chinese medical journal |
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| PublicationYear | 2017 |
| Publisher | Medknow Publications and Media Pvt. Ltd Lippincott Williams & Wilkins Ovid Technologies Department of Cardiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China Key Laboratory of Major Disease in Children, Ministry of Health, Beijing 100045, China%Pediatric Cardiac Intensive Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China%Chinese Academy of Medical Sciences and Comparative Medical Center, Beijing 100021, China Medknow Publications & Media Pvt Ltd Wolters Kluwer |
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| Snippet | Background： Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease （KD）. This study sought... Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate... Background: Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought... Background:Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD).This study sought to... |
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| SubjectTerms | Abnormalities Analysis Animals Cardiology Children & youth Coronary arteries Coronary Artery Disease - diagnostic imaging Coronary vessels Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Diagnosis Disease Model; Echocardiography; Kawasaki Disease; Murine Disease Models, Animal Echocardiography Echocardiography - methods Heart Heart Defects, Congenital - diagnostic imaging Hospitals Kawasaki disease Kawasaki syndrome Laboratory animals Male Mice Mice, Inbred C57BL Mucocutaneous Lymph Node Syndrome - diagnostic imaging Original Pathogenesis Pediatrics Rheumatic fever Rodents Software Studies Ultrasonography - methods Veins & arteries |
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| Title | Echocardiographic Evaluation of Coronary Abnormalities and Cardiac Function in a Murine Model of Kawasaki Disease Using High-frequency Ultrasound |
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