Induced Effects of Sodium Ions on Dopaminergic G-Protein Coupled Receptors

• Published in: PLoS computational biology Vol. 6; no. 8; p. e1000884
• Main Authors: Selent, Jana, Sanz, Ferran, Pastor, Manuel, De Fabritiis, Gianni
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2010; Public Library of Science (PLoS)
• Subjects: Allosteric Regulation; Allosteric Site; Biochemistry; Biophysics; Cell receptors; Chemical properties; Computational Biology; Computational Biology/Molecular Dynamics; Conformation; Genoma humà; Health aspects; Humans; Molecular Dynamics Simulation; Properties; Protein binding; Protein Conformation; Proteins; Proteïnes; Receptors, Adrenergic, beta-2 - chemistry; Receptors, Dopamine D2 - chemistry; Receptors, G-Protein-Coupled - chemistry; Signal transduction; Simulation; Sodium; Sodium - chemistry; Sodium compounds; Studies; Spain; Sodium; Allosteric Regulation; Humans; Allosteric Site; Receptors, Dopamine D2; Receptors, G-Protein-Coupled; Protein Conformation; Receptors, Adrenergic, beta-2; Molecular Dynamics Simulation

G-protein coupled receptors, the largest family of proteins in the human genome, are involved in many complex signal transduction pathways, typically activated by orthosteric ligand binding and subject to allosteric modulation. Dopaminergic receptors, belonging to the class A family of G-protein cou...