Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM): novel biological insights and development of early treatment strategies

• Published in: Blood Vol. 117; no. 21; pp. 5573 - 5581
• Main Authors: Korde, Neha, Kristinsson, Sigurdur Y., Landgren, Ola
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 26.05.2011; Americain Society of Hematology; American Society of Hematology
• Subjects: Biological and medical sciences; Clinical Trials and Observations; Hematologic and hematopoietic diseases; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulinopathies; Immunopathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoid Neoplasia; Medical sciences; Medicin och hälsovetenskap; Monoclonal Gammopathy of Undetermined Significance - therapy; Multiple Myeloma - therapy; Prognosis; Review; Immunopathology; Immunoglobulinopathy; Hematology; Lymphoproliferative syndrome; Early stage; Malignant hemopathy; Asymptomatic; Myeloma; Cancer; Monoclonal gammopathy of undetermined significance

Monoclonal gammopathy of unknown significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic plasma cell dyscrasias, with a propensity to progress to symptomatic MM. In recent years there have been improvements in risk stratification models (involving molecular markers) of both disord...