Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study

• Published in: The Lancet infectious diseases Vol. 20; no. 11; pp. 1263 - 1271
• Main Authors: Meredith, Luke W, Hamilton, William L, Warne, Ben, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Forrest, Sally, Sridhar, Sushmita, Weekes, Michael P, Baker, Stephen, Brown, Nicholas, Moore, Elinor, Popay, Ashley, Roddick, Iain, Reacher, Mark, Gouliouris, Theodore, Peacock, Sharon J, Dougan, Gordon, Török, M Estée, Goodfellow, Ian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.11.2020; Elsevier B.V; Elsevier Limited; The Authors. Published by Elsevier Ltd
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Betacoronavirus - genetics; Child; Child, Preschool; Coronavirus Infections - epidemiology; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; Coronaviruses; COVID-19; Cross Infection - epidemiology; Cross Infection - prevention & control; Cross Infection - virology; Diagnostic systems; DNA sequencing; England - epidemiology; Epidemiology; Female; Genetic research; Genome, Viral - genetics; Genomes; Genomic analysis; Genomics; Health aspects; Health care; Health policy; Hospitals, University; Humans; Infant; Infant, Newborn; Infection Control - methods; Infectious diseases; Investigations; Male; Medical research; Medicine, Experimental; Middle Aged; Nosocomial infections; Nucleotide sequencing; Pandemics - prevention & control; Patient Safety; Patients; Phylogeny; Pneumonia, Viral - epidemiology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - virology; Polymerase Chain Reaction - methods; Polymorphism, Single Nucleotide; Porosity; Prospective Studies; Public health; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Surveillance; Target recognition; Viral diseases; Whole Genome Sequencing - methods; Young Adult; England; United Kingdom > UK

The burden and influence of health-care associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the use of rapid SARS-CoV-2 sequencing combined with detailed epidemiological analysis to investigate health-care associated SARS-CoV-2 infection...