Peripheral biomarkers and illness activity in bipolar disorder

• Published in: Journal of psychiatric research Vol. 45; no. 2; pp. 156 - 161
• Main Authors: Kapczinski, Flávio, Dal-Pizzol, Felipe, Teixeira, Antonio Lucio, Magalhaes, Pedro V.S., Kauer-Sant’Anna, Márcia, Klamt, Fábio, Moreira, José Claudio F., Augusto de Bittencourt Pasquali, Mateus, Fries, Gabriel Rodrigo, Quevedo, João, Gama, Clarissa Severino, Post, Robert
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.02.2011; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Allostatic load; Biological and medical sciences; Biological markers; Biomarkers; Biomarkers - metabolism; Bipolar affective disorder; Bipolar disorder; Bipolar Disorder - metabolism; Bipolar Disorder - physiopathology; Bipolar disorders; Brain; Brain-Derived Neurotrophic Factor - blood; Case-Control Studies; Cell death; Cytokines - blood; Enzyme-Linked Immunosorbent Assay - methods; Female; Humans; Illness activity; Illness Behavior; Indexing in process; Inflammation; Male; Medical sciences; Middle Aged; Mood disorders; Moods; Nervous system; Neurotrophin 3 - blood; Neurotrophins; Oxidative stress; Protein Carbonylation; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Sepsis; Statistics as Topic; Thiobarbituric Acid Reactive Substances - metabolism; Oxidative stress; Biomarkers; Allostatic load; Bipolar disorder; Sepsis; Inflammation; Neurotrophins; Illness activity; Mood disorder; Neurotrophin; Biological marker; Allostasis; Infection; Sepsis syndrome

Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of p...