Glutamatergic Gene Expression Is Specifically Reduced in Thalamocortical Projecting Relay Neurons in Schizophrenia

• Published in: Biological psychiatry (1969) Vol. 70; no. 7; pp. 646 - 654
• Main Authors: Sodhi, Monsheel S., Simmons, Micah, McCullumsmith, Robert, Haroutunian, Vahram, Meador-Woodruff, James H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2011
• Subjects: Carrier Proteins - biosynthesis; Cerebral Cortex - metabolism; GABAergic Neurons - metabolism; Gene Expression; Humans; Interneurons - metabolism; Laser capture microdissection; Laser Capture Microdissection - methods; medial dorsal thalamus; Nerve Tissue Proteins - biosynthesis; Neural Pathways - metabolism; Neuroglia - metabolism; Neurons - metabolism; postmortem gene expression; Psychiatry; ras GTPase-Activating Proteins - biosynthesis; receptor; Receptors, Glutamate - biosynthesis; Schizophrenia - metabolism; Thalamus - metabolism; Laser capture microdissection; postmortem gene expression; receptor; medial dorsal thalamus

Impairment of glutamate neurons that relay sensory and cognitive information from the medial dorsal thalamus to the dorsolateral prefrontal cortex and other cortical regions may contribute to the pathophysiology of schizophrenia. In this study, we have assessed the cell-specific expression of glutam...