Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes - Ebihara, Ken; Ogawa, Yoshihiro; Masuzaki, Hiroaki; Shintani, Mitsuyo; Miyanaga, Fumiko; Aizawa-Abe, Megumi; Hayashi, Tatsuya; Hosoda, Kiminori; Inoue, Gen; Yoshimasa, Yasunao; Gavrilova, Oksana; Reitman, Marc L.; et al. (Diabetes (New York, N.Y.), 2001)
Keywords: Adipocytes; Adipose tissue; Adipose tissues; Animals; Antidiabetics; Biological and medical sciences; Blood Glucose - analysis; Body fat; Body Weight - drug effects; Diabetes; Diabetes Mellitus, Lipoatrophic - drug therapy; Diabetes Mellitus, Lipoatrophic - pathology; Diabetes Mellitus, Lipoatrophic - physiopathology; Diabetes research; Diabetes. Impaired glucose tolerance; Eating; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty acids; Food; Gene Expression; Genetically modified mice; Glucose; Infusion Pumps; Injections; Insulin; Insulin Resistance; Leptin; Leptin - administration & dosage; Leptin - blood; Leptin - genetics; Leptin - therapeutic use; Lipids - blood; Medical sciences; Metabolism; Mice; Mice, Inbred Strains; Mice, Transgenic - genetics; Organ Size; Physiological aspects; Plasma; Transgenes - genetics; Transgenic animals; Variance analysis; Japan; Endocrinopathy; Animal model; Pancreatic hormone; Rodentia; Transgenic animal; Gene overexpression; Lipoatrophic diabetes; Insulin; Target tissue resistance; Vertebrata; Mammalia; Mouse; Leptin