The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis

• Published in: Asian journal of andrology Vol. 22; no. 1; pp. 79 - 87
• Main Authors: Li, Yang, Liu, Wen-Sheng, Yi, Jia, Kong, Shuang-Bo, Ding, Jian-Cheng, Zhao, Yi-Nan, Tian, Ying-Pu, Feng, Gen-Sheng, Li, Chao-Jun, Liu, Wen, Wang, Hai-Bin, Lu, Zhong-Xian
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer India Pvt. Ltd 01.01.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Ability tests; Amino acids; Biotechnology; cell differentiation; gene expression; spermatogenesis; transgenic mouse; Cell division; Genes; Growth factors; Immunoglobulins; Kinases; Leukemia; Life sciences; Medical research; Morphology; Original; Phenols (Class of compounds); Phosphatase; Phosphatases; Proteins; Rodents; Spermatogenesis; Stem cells; Tyrosine; China; Beijing China; United States > US; spermatogenesis; cell differentiation; transgenic mouse; gene expression

The transition from spermatogonia to spermatocytes and the initiation of meiosis are key steps in spermatogenesis and are precisely regulated by a plethora of proteins. However, the underlying molecular mechanism remains largely unknown. Here, we report that Src homology domain tyrosine phosphatase...