1035-P: Early Pregnancy Alterations in the Metabolome of Obese Women

• Published in: Diabetes (New York, N.Y.) Vol. 71; no. Supplement_1
• Main Authors: BANDRES-MERIZ, JULIA, KUNZ, CHRISTINA, HAVELUND, JESPER, FÆRGEMAN, NILS J., HURTADO DE MENDOZA, IRENE, MAJALI-MARTINEZ, ALEJANDRO, ENSENAUER, REGINA, DESOYE, GERNOT
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2022
• Subjects: Adipose tissue; Body weight; Diabetes; Discriminant analysis; Ethanolamine; Gestational age; Glucose; High-performance liquid chromatography; Hyperinsulinemia; Insulin; Leptin; Lipids; Metabolites; Metabolomics; Obesity; Overweight; Palmitoleic acid; Peptides; Pregnancy; Womens health

Obesity in human pregnancy associates with changes in the glucose-insulin axis. We hypothesized that these changes affect the maternal metabolome already in the first trimester, and thus aimed to identify these metabolites. We performed untargeted metabolomics (HPLC-MS/MS) on maternal serum (n=111,...