303-OR: Notch Signaling Inhibitor ADPO-002 Promotes Browning in Human Adipose Tissue Explants

• Published in: Diabetes (New York, N.Y.) Vol. 73; no. Supplement_1; p. 1
• Main Authors: RAISUL ABEDIN, MUHAMMAD, FREIJE, WILSON, OSWALT, MALLORY A., ACTON, ANTHONY J., CRAWFORD, CHRISTOPHER B., INMAN, MARGARET M., CONSIDINE, ROBERT V., DENG, MENG
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 14.06.2024
• Subjects: Adipocytes; Adipose tissue; Body fat; Dexamethasone; Drug development; Explants; Forskolin; Gastrointestinal surgery; Nanoparticles; Organ culture; Secretase; Tissue culture

Introduction: Transformation of white adipocytes into beige adipocytes, known as adipocyte browning, holds great promise for development of new therapeutics. Our previous studies have demonstrated nanoparticle-based delivery of dibenzazepine (ADPO-002), a γ-secretase inhibitor, induces browning of w...