1499-P: Adipocyte Development from Mesenchymal Progenitor Cells Differ between Subjects with Normal Glucose Tolerance or Type 2 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Authors: CORVERA, SILVIA, DESOUZA, TIFFANY A., ZIEGLER, RACHEL N., ROSANO, NINA, THOMPSON, MICHAEL J.
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20.06.2023
• Subjects: Adipocytes; Adipose tissue; Angiogenesis; Body fat; Diabetes; Diabetes mellitus (non-insulin dependent); Explants; Glucose tolerance; Hydrogels; Insulin resistance; Lipids; Progenitor cells; Transcriptomics

Subcutaneous adipose tissue protects from T2D by sequestering lipids and preventing lipotoxicity and insulin resistance. Adipose depots are maintained throughout the lifetime by the formation of new adipocytes from mesenchymal progenitor cells that reside within the tissue. In previous studies, we h...