Optimal electrical stimulation boosts stem cell therapy in nerve regeneration

• Published in: Biomaterials Vol. 181; pp. 347 - 359
• Main Authors: Du, Jian, Zhen, Gehua, Chen, Huanwen, Zhang, Shuming, Qing, Liming, Yang, Xiuli, Lee, Gabsang, Mao, Hai-Quan, Jia, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2018
• Subjects: Animals; autografting; cathodes; Cell Differentiation - physiology; cell viability; Cells, Cultured; Electric Stimulation - methods; Electrical stimulation; electrical treatment; gait; Human neural crest stem cell; Humans; Immunohistochemistry; muscles; Nerve regeneration; Nerve Regeneration - physiology; nerve tissue; neural crest; Neural Crest - cytology; Neural Stem Cells - cytology; Neural Stem Cells - physiology; Neurogenesis - physiology; neurons; people; Peripheral Nerve Injuries - therapy; Peripheral nerve injury; Pluripotent stem cells; Rats; Stem Cell Transplantation - methods; stem cells; tissue transplantation; United States; United States; Electrical stimulation; Peripheral nerve injury; Pluripotent stem cells; Nerve regeneration; Human neural crest stem cell

Peripheral nerve injuries often lead to incomplete recovery and contribute to significant disability to approximately 360,000 people in the USA each year. Stem cell therapy holds significant promise for peripheral nerve regeneration, but maintenance of stem cell viability and differentiation potenti...