In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector - Komatsu, Yumiko; Tanaka, Chiaki; Komorizono, Ryo; Tomonaga, Keizo (Scientific reports, 2020)
Keywords: 631/1647/2300; 631/326/596/2561; Animals; Animals, Genetically Modified; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Astrocytes; Astrocytes - metabolism; Body weight; Brain - metabolism; CD8 antigen; Feasibility Studies; Feces - virology; Female; Gene Expression; Gene transfer; Genetic Vectors - administration & dosage; Genetic Vectors - genetics; Genetic Vectors - isolation & purification; Genetic Vectors - pharmacokinetics; Humanities and Social Sciences; Lymphocytes T; Microglia; Microglia - metabolism; multidisciplinary; Neurons - metabolism; Pathogenicity; Pathogens; Plasmids - genetics; Rats; Rats, Inbred Lew; RNA viruses; RNA Viruses - genetics; RNA Viruses - immunology; RNA Viruses - isolation & purification; Science; Science (multidisciplinary); Tissue Distribution; Transduction, Genetic; Transgenes - genetics; Tropism; Virus Replication; Virus Shedding