A cytoarchitecture-driven myelin model reveals area-specific signatures in human primary and secondary areas using ultra-high resolution in-vivo brain MRI

• Published in: NeuroImage (Orlando, Fla.) Vol. 114; pp. 71 - 87
• Main Authors: Dinse, J., Härtwich, N., Waehnert, M.D., Tardif, C.L., Schäfer, A., Geyer, S., Preim, B., Turner, R., Bazin, P.-L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2015; Elsevier Limited
• Subjects: Adult; Boundaries; Brain; Brain Mapping - methods; Cerebral Cortex - cytology; Cortical areas; Cortical profiles; Cytoarchitecture; Female; Histology; Human; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - methods; Male; Modelling ultra-high resolution; Motor Cortex - cytology; Myelin; Myelin Sheath; Myeloarchitecture; Quantitative MRI; Signatures; Somatosensory Cortex - cytology; Spatial distribution; Standard deviation; Studies; Young Adult; Myeloarchitecture; Cortical areas; Modelling ultra-high resolution; Cytoarchitecture; Cortical profiles; Quantitative MRI

This work presents a novel approach for modelling laminar myelin patterns in the human cortex in brain MR images on the basis of known cytoarchitecture. For the first time, it is possible to estimate intracortical contrast visible in quantitative ultra-high resolution MR images in specific primary a...