Darwinian Evolution of Prions in Cell Culture - Li, Jiali; Browning, Shawn; Mahal, Sukhvir P; Oelschlegel, Anja M; Weissmann, Charles (Science (American Association for the Advancement of Science), 2010)
Keywords: Animals; Biological and medical sciences; Biological evolution; brain; Brain Chemistry; Cell culture; Cell culture techniques; Cell Line; Cell Line, Tumor; Cellular biology; Culture Media; Culture Media, Conditioned; Cultured cells; Darwinism; Evolution; Evolution, Molecular; Evolutionary biology; Fundamental and applied biological sciences. Psychology; Genetic mutation; Genetics of eukaryotes. Biological and molecular evolution; genome; Infections; Mice; Mice, Inbred C57BL; Microbiology; Molecular and cellular biology; mutants; Mutation; Nervous system diseases; Non conventional transmissible agents; Nucleic acids; Polysaccharides; Prion Diseases; Prions; Prions - chemistry; Prions - classification; Prions - pathogenicity; Prions - physiology; Protein Conformation; Proteins; PrPSc proteins; PrPSc Proteins - chemistry; PrPSc Proteins - classification; PrPSc Proteins - pathogenicity; swainsonine; Swainsonine - pharmacology; Amplification; Cell culture; Molecular evolution; Prion; Mutation