Kinetics of viral load and antibody response in relation to COVID-19 severity

• Published in: The Journal of clinical investigation Vol. 130; no. 10; pp. 5235 - 5244
• Main Authors: Wang, Yanqun, Zhang, Lu, Sang, Ling, Ye, Feng, Ruan, Shicong, Zhong, Bei, Song, Tie, Alshukairi, Abeer N., Chen, Rongchang, Zhang, Zhaoyong, Gan, Mian, Zhu, Airu, Huang, Yongbo, Luo, Ling, Mok, Chris Ka Pun, Al Gethamy, Manal M., Tan, Haitao, Li, Zhengtu, Huang, Xiaofang, Li, Fang, Sun, Jing, Zhang, Yanjun, Wen, Liyan, Li, Yuming, Chen, Zhao, Zhuang, Zhen, Zhuo, Jianfen, Chen, Chunke, Kuang, Lijun, Wang, Junxiang, Lv, Huibin, Jiang, Yongliang, Li, Min, Lin, Yimin, Deng, Ying, Tang, Lan, Liang, Jieling, Huang, Jicheng, Perlman, Stanley, Zhong, Nanshan, Zhao, Jingxian, Malik Peiris, J.S., Li, Yimin, Zhao, Jincun
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.10.2020
• Subjects: Adult; Aged; Antibodies, Viral - blood; Antibody Specificity; Antigen-antibody reactions; Betacoronavirus - metabolism; Coronavirus infections; Coronavirus Infections - blood; Coronaviruses; COVID-19; Cross Reactions; Female; Humans; Immunoglobulin G; Kinetics; Male; Medical research; Medicine, Experimental; Middle Aged; Pandemics; Pneumonia, Viral - blood; SARS-CoV-2; Severity of Illness Index; Viral Load; Virus Shedding; Middle East; China; Infectious disease; Adaptive immunity; Molecular diagnosis; Molecular biology; Virology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus 2019 (COVID-19) pneumonia. Little is known about the kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients with COVID-19. Two groups of patients with RT-PCR...