IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma
Abstract Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation...
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| Published in | Cancer letters Vol. 336; no. 1; pp. 222 - 230 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
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| Abstract | Abstract Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induced apoptosis while the C-terminal domain inhibited cell migration and invasion. The Linker domain had no independent effects. In vivo , the N-terminal domain decreased tumor growth without affecting pulmonary metastases while the C-terminal domain inhibited tumor growth and metastases. In summary, the N- and C-terminal domains modulated OS tumorigenic phenotypes while the C-terminal domain inhibited OS metastatic phenotypes. |
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| AbstractList | Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induced apoptosis while the C-terminal domain inhibited cell migration and invasion. The Linker domain had no independent effects. In vivo, the N-terminal domain decreased tumor growth without affecting pulmonary metastases while the C-terminal domain inhibited tumor growth and metastases. In summary, the N- and C-terminal domains modulated OS tumorigenic phenotypes while the C-terminal domain inhibited OS metastatic phenotypes. Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induced apoptosis while the C-terminal domain inhibited cell migration and invasion. The Linker domain had no independent effects. In vivo , the N-terminal domain decreased tumor growth without affecting pulmonary metastases while the C-terminal domain inhibited tumor growth and metastases. In summary, the N- and C-terminal domains modulated OS tumorigenic phenotypes while the C-terminal domain inhibited OS metastatic phenotypes. Abstract Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induced apoptosis while the C-terminal domain inhibited cell migration and invasion. The Linker domain had no independent effects. In vivo , the N-terminal domain decreased tumor growth without affecting pulmonary metastases while the C-terminal domain inhibited tumor growth and metastases. In summary, the N- and C-terminal domains modulated OS tumorigenic phenotypes while the C-terminal domain inhibited OS metastatic phenotypes. |
| Author | Lamplot, Joseph Kim, Stephanie H Wagner, Eric R Parekh, Akash Chen, Xiang Liu, Xing Haydon, Rex C He, Tong-Chuan Rames, Richard Huang, Enyi Luu, Hue H Shen, Jikun Luther, Gaurav A |
| AuthorAffiliation | 1 Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL, USA 4 School of Bioengineering, Chongqing University, Chongqing, China 3 The Stem Cell Biology and Therapy Laboratory and the Department of Pediatric Orthopaedics, The Children’s Hospital of Chongqing Medical University, Chongqing, China 2 Department of Orthopaedic Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi’an, China |
| AuthorAffiliation_xml | – name: 2 Department of Orthopaedic Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi’an, China – name: 3 The Stem Cell Biology and Therapy Laboratory and the Department of Pediatric Orthopaedics, The Children’s Hospital of Chongqing Medical University, Chongqing, China – name: 4 School of Bioengineering, Chongqing University, Chongqing, China – name: 1 Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL, USA |
| Author_xml | – sequence: 1 fullname: Luther, Gaurav A – sequence: 2 fullname: Lamplot, Joseph – sequence: 3 fullname: Chen, Xiang – sequence: 4 fullname: Rames, Richard – sequence: 5 fullname: Wagner, Eric R – sequence: 6 fullname: Liu, Xing – sequence: 7 fullname: Parekh, Akash – sequence: 8 fullname: Huang, Enyi – sequence: 9 fullname: Kim, Stephanie H – sequence: 10 fullname: Shen, Jikun – sequence: 11 fullname: Haydon, Rex C – sequence: 12 fullname: He, Tong-Chuan – sequence: 13 fullname: Luu, Hue H |
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| Keywords | Animal model Metastasis IGFBP5 Insulin-like growth factor binding protein Osteosarcoma |
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| Snippet | Abstract Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5)... Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in... |
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| SubjectTerms | Adenoviruses Animal model Animals Apoptosis Bone Neoplasms - metabolism Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement Cell Proliferation Extracellular matrix Gene Expression Regulation, Neoplastic HEK293 Cells Hematology, Oncology and Palliative Medicine Humans Hydroxyapatite IGFBP5 Insulin-like growth factor binding protein Insulin-Like Growth Factor Binding Protein 5 - metabolism Insulin-like growth factors Metastasis Mice Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Transplantation Osteosarcoma Osteosarcoma - metabolism Pathogenesis Phenotype Protein Interaction Domains and Motifs Proteins Time Factors |
| Title | IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma |
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