HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy

• Published in: The Journal of clinical investigation Vol. 132; no. 1
• Main Authors: Kanchan, Kanika, Grinek, Stepan, Bahnson, Henry T., Ruczinski, Ingo, Shankar, Gautam, Larson, David, Du Toit, George, Barnes, Kathleen C., Sampson, Hugh A., Suarez-Farinas, Mayte, Lack, Gideon, Nepom, Gerald T., Cerosaletti, Karen, Mathias, Rasika A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.01.2022
• Subjects: 2S Albumins, Plant - immunology; Alleles; Allelomorphism; Antibody Formation - genetics; Antibody Formation - immunology; Antigens, Plant - immunology; Arachis; Child; Female; Genetic aspects; Genetics; Health aspects; Histocompatibility antigens; HLA histocompatibility antigens; HLA-DQ alpha-Chains - genetics; HLA-DQ alpha-Chains - immunology; Humans; Immune response; Immunoglobulin G; Immunoglobulin G - immunology; Immunology; Male; Peanut allergy; Peanut Hypersensitivity - genetics; Peanut Hypersensitivity - immunology; Prevention; United States; MHC class 1; Genetics; Immunology; MHC class 2; Genetic variation

We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted intervention in the LEAP clinical trial. We identified an association between peanut-specific IgG4 and HLA-DQA1*01:02 that was only observed...