Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin

• Published in: Biological & pharmaceutical bulletin Vol. 25; no. 1; pp. 81 - 86
• Main Authors: Sato, Mayumi, Tai, Takaaki, Nunoura, Yoshiki, Yajima, Yukiko, Kawashima, Seiichi, Tanaka, Keiji
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 2002; Maruzen; Japan Science and Technology Agency
• Subjects: adipocyte differentiation; Adipocytes - drug effects; Animals; Biological and medical sciences; Cell Differentiation - drug effects; Cells, Cultured; dehydrotrametenolic acid; Diabetes Mellitus, Type 2 - drug therapy; General and cellular metabolism. Vitamins; Hydrolysis; Hypoglycemic Agents - therapeutic use; Insulin - pharmacology; Male; Medical sciences; Mice; Mice, Inbred C57BL; noninsulin-dependent diabetes mellitus; Obesity - metabolism; pachymic acid; peroxisome proliferator-activated receptor γ (PPAR γ); Pharmacology. Drug treatments; Plasmids - genetics; Polyporaceae - chemistry; Proteins - metabolism; Receptors, Cytoplasmic and Nuclear - metabolism; Stem Cells - drug effects; Transcription Factors - metabolism; Transfection; Triglycerides - metabolism; triterpene; Triterpenes - pharmacology; Asia; China; Endocrinopathy; Pancreatic hormone; Ciglitazone; Basidiomycetes; Non insulin dependent diabetes; Fungi; Poria; Hypoglycemic agent; Folk medicine; Mechanism of action; Peroxisome proliferator activated receptor; Thallophyta; Sclerotia; Rodentia; Parasite; Glucose tolerance test; Insulin; Biological activity; Vertebrata; Mammalia; Microbial origin; Mouse; Animal; Polyporus; Comparative study

We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos Wolf (Polyporaceae), a well-known traditional Chinese me...