The neurobiology and treatment of first-episode schizophrenia

• Published in: Molecular psychiatry Vol. 20; no. 1; pp. 84 - 97
• Main Authors: Kahn, R S, Sommer, I E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2015; Nature Publishing Group
• Subjects: 631/378/2649; 631/378/340; 692/699/476/1799; 692/700/565; Age of Onset; Anniversaries; Antipsychotic Agents - therapeutic use; Antipsychotics; Behavioral Sciences; Biological Psychology; Brain - pathology; Care and treatment; Cognition Disorders - etiology; Dopamine; Expert Review; Humans; Longitudinal studies; Medical imaging; Medicine; Medicine & Public Health; Neurobiology; Neuroimaging; Neurophysiology; Neurosciences; Pharmacotherapy; Physiological aspects; Psychiatric research; Psychiatry; Psychosis; Psychotropic drugs; Receptors, N-Methyl-D-Aspartate - metabolism; Schizophrenia; Schizophrenia - complications; Schizophrenia - genetics; Schizophrenia - pathology; Schizophrenia - therapy; Netherlands

It is evident that once psychosis is present in patients with schizophrenia, the underlying biological process of the illness has already been ongoing for many years. At the time of diagnosis, patients with schizophrenia show decreased mean intracranial volume (ICV) as compared with healthy subjects...