IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

• Published in: Neuron (Cambridge, Mass.) Vol. 85; no. 3; pp. 519 - 533
• Main Authors: Chakrabarty, Paramita, Li, Andrew, Ceballos-Diaz, Carolina, Eddy, James A., Funk, Cory C., Moore, Brenda, DiNunno, Nadia, Rosario, Awilda M., Cruz, Pedro E., Verbeeck, Christophe, Sacino, Amanda, Nix, Sarah, Janus, Christopher, Price, Nathan D., Das, Pritam, Golde, Todd E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.02.2015; Elsevier Limited
• Subjects: Adeno-associated virus; Alzheimer's disease; Amyloid beta-Protein Precursor - genetics; Animal cognition; Animals; Animals, Newborn; Cells, Cultured; Cognition Disorders - immunology; Cognition Disorders - metabolism; HEK293 Cells; Humans; Hypotheses; Immune system; Immunoproteins - biosynthesis; Interleukin-10 - biosynthesis; Memory; Mice; Mice, Transgenic; Neurodegeneration; Plaque, Amyloid - immunology; Plaque, Amyloid - metabolism; Proteostasis Deficiencies - immunology; Proteostasis Deficiencies - metabolism; Rodents

Anti-inflammatory strategies are proposed to have beneficial effects in Alzheimer’s disease. To explore how anti-inflammatory cytokine signaling affects Aβ pathology, we investigated the effects of adeno-associated virus (AAV2/1)-mediated expression of Interleukin (IL)-10 in the brains of APP transg...