Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma

• Published in: Oncogene Vol. 35; no. 24; pp. 3209 - 3216
• Main Authors: Schabath, M B, Welsh, E A, Fulp, W J, Chen, L, Teer, J K, Thompson, Z J, Engel, B E, Xie, M, Berglund, A E, Creelan, B C, Antonia, S J, Gray, J E, Eschrich, S A, Chen, D-T, Cress, W D, Haura, E B, Beg, A A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.06.2016; Nature Publishing Group
• Subjects: 38/23; 38/39; 38/61; 631/208; 631/67; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - immunology; Adenocarcinoma - pathology; Adenocarcinoma of Lung; AMP-Activated Protein Kinase Kinases; Apoptosis; Biology; Cancer; Care and treatment; Cell Biology; Cell growth; Cell proliferation; Cell Proliferation - genetics; Development and progression; DNA microarrays; Female; Gene Expression; Gene mutations; Genes, ras; Genetic aspects; Genetic suppression; Health aspects; Human Genetics; Humans; Immunologic Surveillance - genetics; Immunosurveillance; Immunotherapy; Internal Medicine; K-Ras protein; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Mutants; Mutation; oncogenomics; Oncology; p53 Protein; Properties; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - immunology; Proto-Oncogene Proteins p21(ras) - biosynthesis; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - immunology; Signal Transduction; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - immunology; Tumors; United States

While mutations in the KRAS oncogene are among the most prevalent in human cancer, there are few successful treatments to target these tumors. It is also likely that heterogeneity in KRAS -mutant tumor biology significantly contributes to the response to therapy. We hypothesized that the presence of...