Accelerated Production of Nucleosome in Cultured Human Mononuclear Cells in Untreated Graves' Disease

• Published in: ENDOCRINE JOURNAL Vol. 49; no. 2; pp. 189 - 194
• Main Authors: HARA, HIDEO, SATO, RYUJI, BAN, YOSHIO
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 2002
• Subjects: Adult; Apoptosis - immunology; Caspase 3; Caspases - immunology; Caspases - metabolism; Cultured mononuclear cell; Cytochrome c Group - immunology; Cytochrome c Group - metabolism; DNA - chemistry; Fas Ligand Protein; fas Receptor - immunology; fas Receptor - metabolism; Female; Graves Disease - blood; Graves Disease - immunology; Graves' disease; Humans; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - pathology; Male; Membrane Glycoproteins - immunology; Membrane Glycoproteins - metabolism; Middle Aged; Nucleosome; Nucleosomes - immunology; Nucleosomes - metabolism; Thyroiditis, Autoimmune - blood; Thyroiditis, Autoimmune - immunology; Thyrotropin - blood; Thyroxine - blood; Triiodothyronine - blood

The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas ligand system. As the assay of nucleosomes produced by apoptotic cells can be used to quantitate apoptosis, we evaluated nucleosome and soluble Fas ligand (sFasL) levels of cultured mononuclear cells...