DNA fragmentation of lymphocytes and sperm cells induced by nickel released from orthodontic archwires: A preliminary study

• Published in: Dental Materials Journal Vol. 43; no. 4; pp. 539 - 545
• Main Authors: UMAÑA, José Alfredo FACIO, Roberto BELTRAN DEL RIO PARRA, MARTÍNEZ, Raúl Uriel MEDINA, MARTÍNEZ, Nadia BETANCOURT, LUNA, Pedro IV GONZÁLEZ, MARTÍNEZ, Javier MORÁN
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Dental Materials and Devices 25.07.2024; Japanese Society for Dental Materials and Devices; Japan Science and Technology Agency
• Subjects: Adult; Archwires; Bioassays; Comet Assay; Concentration cell corrosion; Corrosion cell; Corrosion tests; Cytotoxicity; Damage detection; Deoxyribonucleic acid; DNA; DNA damage; DNA Fragmentation; Fragmentation; Humans; Lymphocytes; Lymphocytes - drug effects; Male; Metal ions; Nickel; Nickel compounds; NiTi archwires; Orthodontic Wires; Orthodontics; Placement; Semen; Sperm; Sperm cells; Spermatozoa - drug effects; Structural damage; Titanium; Urine; NiTi archwires; Lymphocytes; Sperm cells; DNA fragmentation

Orthodontic brackets and archwires placed intraorally are subject to corrosion, leading to the release of cytotoxic metal ions. The aim of this study was to determine whether the use of orthodontic NiTi archwires increases systemic Ni levels and cause alterations on the DNA of cells unrelated to the...