Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

• Published in: Nature (London) Vol. 407; no. 6806; pp. 913 - 916
• Main Authors: Chitnis, Ajay B, Kim, Cheol-Hee, Oda, Takaya, Itoh, Motoyuki, Jiang, Di, Artinger, Kristin Bruk, Chandrasekharappa, Settara C, Driever, Wolfgang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 19.10.2000; Nature Publishing Group
• Subjects: Animals; Biological and medical sciences; Chromosome Mapping; Cloning, Molecular; Danio rerio; Embryology: invertebrates and vertebrates. Teratology; Fish; Freshwater; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Genetics; Head; Head - abnormalities; Head - embryology; headless gene; HMGB Proteins; Mutation; Organizers, Embryonic; Organogenesis. Fetal development; Organogenesis. Physiological fonctions; Proto-Oncogene Proteins - metabolism; Repressor Proteins - genetics; Repressor Proteins - physiology; Signal Transduction; T-cell factor-3; TCF Transcription Factors; Tcf3 protein; Transcription Factor 7-Like 1 Protein; Transcription Factors - genetics; Transcription Factors - physiology; Vertebrates; Wnt protein; Wnt Proteins; Zebrafish - embryology; Zebrafish Proteins; Morphogenesis; Embryonic development; Signal transduction; Vertebrata; Brachydanio rerio; Embryo; Head; Gastrulation; Gene; Pisces; Mutation

The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo by virtue of its distinct head and trunk inducing properties. Wingless/Wnt antagonists secreted by the organizer have been identified as head inducers. Their ectopic expression can promote...