Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence

• Published in: PLoS biology Vol. 22; no. 4; p. e3002559
• Main Authors: Wu, Deng, Sun, Jacquelyne Ka-Li, Chow, Kim Hei-Man
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.04.2024; Public Library of Science (PLoS)
• Subjects: Aged; Aging; Aging - genetics; Aging - physiology; Algorithms; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Animals; Bioinformatics; Biology and Life Sciences; Brain; Brain - metabolism; Brain - pathology; Brain research; Cell cycle; Cell Cycle - genetics; Cellular Senescence - genetics; Computer and Information Sciences; Cyclin-dependent kinases; Degeneration; Dementia disorders; Deregulation; Dopamine receptors; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Gene expression; Gene Expression Profiling; Health aspects; Humans; Inflammation; Kinases; Lewy bodies; Localization; Male; Medicine and Health Sciences; Metadata; Mice; Mice, Inbred C57BL; Movement disorders; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurons; Neurons - metabolism; Neurons - pathology; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Scholarships & fellowships; Senescence; Short Reports; Transcriptome - genetics; Transcriptomes; Transcriptomics; China

Increasing evidence indicates that terminally differentiated neurons in the brain may recommit to a cell cycle-like process during neuronal aging and under disease conditions. Because of the rare existence and random localization of these cells in the brain, their molecular profiles and disease-spec...