Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

• Published in: The EMBO journal Vol. 28; no. 15; pp. 2244 - 2258
• Main Authors: Vergne, Isabelle, Roberts, Esteban, Elmaoued, Rasha A, Tosch, Valérie, Delgado, Mónica A, Proikas-Cezanne, Tassula, Laporte, Jocelyn, Deretic, Vojo
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 05.08.2009; Nature Publishing Group UK; Springer Nature B.V; EMBO Press; Nature Publishing Group
• Subjects: Amino Acid Substitution - genetics; Animals; Atg18; Autophagy; Biochemistry; Cell Line; Cellular biology; EMBO07; EMBO24; Enzymes; Humans; LC3; Mammals; Membranes; Mice; Molecular biology; Molecular Sequence Data; Mutation, Missense; Myopathies, Structural, Congenital - genetics; myopathy; Pathology; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - physiology; PI3P phosphatase; Sequence Analysis, DNA; PI3P phosphatase; Atg18; autophagy; myopathy; LC3

The majority of studies on autophagy, a cytoplasmic homeostatis pathway of broad biological and medical significance, have been hitherto focused on the phosphatidylinositol 3‐kinases as the regulators of autophagy. Here, we addressed the reverse process driven by phosphoinositide phosphatases and un...