Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19

• Published in: EMBO molecular medicine Vol. 13; no. 1; pp. e13424 - n/a
• Main Authors: Marfia, Giovanni, Navone, Stefania, Guarnaccia, Laura, Campanella, Rolando, Mondoni, Michele, Locatelli, Marco, Barassi, Alessandra, Fontana, Laura, Palumbo, Fabrizio, Garzia, Emanuele, Ciniglio Appiani, Giuseppe, Chiumello, Davide, Miozzo, Monica, Centanni, Stefano, Riboni, Laura
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.01.2021; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: Aged; Apolipoproteins; Biomarkers; Biomarkers - blood; Blood & organ donations; Case-Control Studies; Coronavirus; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 - pathology; Diabetes; EMBO02; EMBO23; Erythrocytes; Female; Ferritin; Fibrinogen; Humans; Hypertension; Intensive care; intensive care unit; L-Lactate dehydrogenase; Lactic acid; Lymphocytes; Lymphopenia; Lysophospholipids - blood; Male; Middle Aged; Mortality; Neutrophils; Pathophysiology; Patients; Prognosis; prognostic biomarker; Prospective Studies; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Sphingosine - analogs & derivatives; Sphingosine - blood; sphingosine‐1‐phosphate; Statistical analysis; Therapeutic targets; prognostic biomarker; intensive care unit; Coronavirus; sphingosine‐1‐phosphate; COVID‐19; COVID-19; sphingosine-1-phosphate

The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐19 patients. One hundred eleven COVID‐19 patients and forty‐seven h...