水通道蛋白AQP4基因缺失加重NMDA诱导的小鼠脑损伤

Q256%Q421; 目的:评价水通道蛋白AQP4在兴奋性氨基酸NMDA诱导脑损伤中起的作用.方法:在AQP4基因敲除小鼠,皮层注射NMDA 150 nmol诱导损伤.甲苯胺蓝染色评价损伤面积,Fluro -Jade B染色评价变性神经元,免疫组化法评价血脑屏障通透性增高.结果:与野生型小鼠比较,AQP4基因缺失加重NMDA诱导的皮层损伤,增加损伤区变性神经元密度,加重血脑屏障通透性的增高.结论:AQP4在NMDA诱导的脑损伤中可能起保护作用....

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Published in浙江大学学报（医学版） Vol. 40; no. 2; pp. 145 - 149
Main Authors 史文珍, 赵春贞, 黄雪琴, 张纬萍, 方三华, 卢韵碧, 魏尔清
Format Journal Article
LanguageChinese
Published 浙江大学医学院药理学系,浙江杭州,310058 2011
Subjects
水通道蛋白质4
脑损伤
小鼠,基因敲除
基因敲除
NMDA
AQP4
皮层注射
N-甲基天冬氨酸/药理学
Online AccessGet full text
ISSN1008-9292
DOI10.3785/j.issn.1008-9292.2011.02.005

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Abstract Q256%Q421; 目的:评价水通道蛋白AQP4在兴奋性氨基酸NMDA诱导脑损伤中起的作用.方法:在AQP4基因敲除小鼠,皮层注射NMDA 150 nmol诱导损伤.甲苯胺蓝染色评价损伤面积,Fluro -Jade B染色评价变性神经元,免疫组化法评价血脑屏障通透性增高.结果:与野生型小鼠比较,AQP4基因缺失加重NMDA诱导的皮层损伤,增加损伤区变性神经元密度,加重血脑屏障通透性的增高.结论:AQP4在NMDA诱导的脑损伤中可能起保护作用.
AbstractList Q256%Q421; 目的:评价水通道蛋白AQP4在兴奋性氨基酸NMDA诱导脑损伤中起的作用.方法:在AQP4基因敲除小鼠,皮层注射NMDA 150 nmol诱导损伤.甲苯胺蓝染色评价损伤面积,Fluro -Jade B染色评价变性神经元,免疫组化法评价血脑屏障通透性增高.结果:与野生型小鼠比较,AQP4基因缺失加重NMDA诱导的皮层损伤,增加损伤区变性神经元密度,加重血脑屏障通透性的增高.结论:AQP4在NMDA诱导的脑损伤中可能起保护作用.
Author 赵春贞
魏尔清
张纬萍
黄雪琴
方三华
史文珍
卢韵碧
AuthorAffiliation 浙江大学医学院药理学系,浙江杭州,310058
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Author_FL ZHAO Chun-zhen
HUANG Xue-qin
LU Yun-bi
ZHANG Wei-ping
SHI Wen-zhen
FANG San-hua
WEI Er-qing
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DocumentTitle_FL Deficiency of water channel AQP4 aggravates NMDA-induced brain injury in mice
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Keywords 水通道蛋白质4
脑损伤
小鼠,基因敲除
基因敲除
NMDA
AQP4
皮层注射
N-甲基天冬氨酸/药理学
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Title 水通道蛋白AQP4基因缺失加重NMDA诱导的小鼠脑损伤
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