The relationship between triglyceride-glucose index and serum neurofilament light chain: Findings from NHANES 2013–2014

• Published in: PloS one Vol. 20; no. 4; p. e0321226
• Main Authors: Chen, Tong, Zheng, Wei, Zhang, Yan, Xu, Qian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.04.2025; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Alcohol; Alzheimer's disease; Analysis; Antibodies; Antigens; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Blood Glucose - analysis; Blood Glucose - metabolism; Blood pressure; Blood sugar; Body mass index; Chains; Cholesterol; Congestive heart failure; Cross-sectional studies; Cytoplasmic filaments; Degeneration; Design; Disease; Female; Glucose; Health aspects; Heart failure; High density; High density lipoprotein; Humans; Hypertension; Insulin; Insulin Resistance; Lipoproteins; Male; Measurement; Medicine and Health Sciences; Metabolism; Middle Aged; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neurofilament Proteins - blood; Normal distribution; Nutrition; Nutrition Surveys; Population; Questionnaires; Regression analysis; Regression models; Statistical analysis; Subgroups; Triglycerides; Triglycerides - blood; Variables; United States; United States > US

The Triglyceride-Glucose (TyG) index has become a reliable indicator for evaluating the level of insulin resistance, a pivotal factor in both metabolic and neurodegenerative disorders. Serum neurofilament light chain (sNfL) serves as a responsive biomarker for detecting neuroaxonal injury. Despite t...