Cinacalcet studies in pediatric subjects with secondary hyperparathyroidism receiving dialysis

• Published in: Pediatric nephrology (Berlin, West) Vol. 35; no. 9; pp. 1679 - 1697
• Main Authors: Warady, Bradley A., Ng, Eric, Bloss, Laura, Mo, May, Schaefer, Franz, Bacchetta, Justine
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2020; Springer; Springer Nature B.V; Springer Verlag
• Subjects: Adolescent; Bone diseases; Calcification (ectopic); Calcimimetic Agents - administration & dosage; Calcimimetic Agents - adverse effects; Calcium homeostasis; Calcium phosphates; Child; Child, Preschool; Children; Chronic kidney failure; Cinacalcet; Cinacalcet - administration & dosage; Cinacalcet - adverse effects; Clinical trials; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Complications and side effects; Dialysis; Diseases; Dosage and administration; Double-Blind Method; Drug therapy; Equivalence Trials as Topic; Female; Fractures; Hemodialysis; Homeostasis; Humans; Hyperparathyroidism; Hyperparathyroidism, Secondary - drug therapy; Hyperparathyroidism, Secondary - etiology; Kidney diseases; Life Sciences; Male; Medicine; Medicine & Public Health; Minerals; Nephrology; Original; Original Article; Parathyroid; Parathyroid hormone; Pediatrics; Phosphorus; Randomized Controlled Trials as Topic; Renal Dialysis - adverse effects; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - therapy; Risk factors; Sterols; Supplements; Testing; Urology; Vitamin D; What's New in Dialysis; United States; Dialysis; Cinacalcet; sHPT; Pediatric; CKD-MBD

Background Secondary hyperparathyroidism (sHPT), a complication of chronic kidney disease (CKD) characterized by persistently elevated parathyroid hormone (PTH), alterations in calcium-phosphorus homeostasis, and vitamin D metabolism, affects 50% of children receiving dialysis. A significant proport...