Hepatic Microenvironment Affects Oval Cell Localization in Albumin-Urokinase-Type Plasminogen Activator Transgenic Mice

• Published in: The American journal of pathology Vol. 162; no. 1; pp. 195 - 202
• Main Authors: Braun, Kristin M., Thompson, Anne W., Sandgren, Eric P.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 2003; ASIP; American Society for Investigative Pathology
• Subjects: Animals; Biological and medical sciences; Cell Count; Cell Division - genetics; Desmin - metabolism; Disease Models, Animal; Gastroenterology. Liver. Pancreas. Abdomen; Hepatectomy; Laminin - metabolism; Liver - growth & development; Liver - metabolism; Liver - pathology; Liver Diseases - genetics; Liver Diseases - pathology; Liver Regeneration - genetics; Liver, biliary tract, pancreas, portal circulation, spleen; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Mice; Mice, Transgenic; Other diseases. Semiology; Recombinant Fusion Proteins - biosynthesis; Recombinant Fusion Proteins - genetics; Regular; Serum Albumin - genetics; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Urokinase-Type Plasminogen Activator - genetics; Immunohistochemistry; Cell proliferation; u-Plasminogen activator; Serine endopeptidases; Enzyme; Stem cell; Liver; Rodentia; Cell microenvironment; Albumin; Transgenic animal; Hepatectomy; Pathology; Peptidases; Regeneration; Vertebrata; Experimental disease; Oval cell; Mammalia; Partial; Mouse; Surgery; Animal; Hydrolases

Mice carrying an albumin-urokinase type plasminogen activator transgene (AL-uPA) develop liver disease secondary to uPA expression in hepatocytes. Transgene-expressing parenchyma is replaced gradually by clones of cells that have deleted transgene DNA and therefore are not subject to uPA-mediated da...