Sex-specific effects of appetite suppressants on stereotypy in rats

• Published in: PloS one Vol. 20; no. 6; p. e0325067
• Main Authors: Lopez, Axl, Gil-Lievana, Elvi, Gutierrez, Ranier
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.06.2025; Public Library of Science (PLoS)
• Subjects: Amphetamines; Animals; Appetite; Appetite depressants; Appetite Depressants - adverse effects; Appetite Depressants - pharmacology; Appetite suppressants; Artificial intelligence; Behavior; Behavior, Animal - drug effects; Biology and Life Sciences; Body weight; Body Weight - drug effects; Body weight loss; Brain research; Complications and side effects; Demographic aspects; Dopamine; Dopamine receptors; Drug delivery; Drug dosages; Drugs; Dyskinesia; Female; Females; Food; Laboratory animals; Male; Males; Medicine and Health Sciences; Network analysis; Obesity; Rats; Rats, Sprague-Dawley; Research and Analysis Methods; Risk factors; Serotonin; Sex; Side effects; Stereotyped behavior; Stereotyped behavior (Psychiatry); Stereotyped Behavior - drug effects; Weaving; Weight control; Weight loss; Weight reduction; Mexico

This study investigated the sex-specific effects of commonly prescribed appetite suppressants on body weight and the manifestation of motor side effects, specifically stereotypy. Employing video recordings and DeepLabCut (DLC) for precise behavioral quantification, we analyzed stereotypy, defined as...