Exploring the mechanism of Synechococcus sp. XM-24 in gastric cancer treatment via network pharmacology and molecular docking

• Published in: PloS one Vol. 20; no. 7; p. e0326664
• Main Authors: Li, Jiayi, Ma, Yamei, Guo, Longzhi, Liu, Junhong, Li, Lin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.07.2025; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; AKT1 protein; Algae; Apoptosis; Bcl-2 protein; Binding; Bioinformatics; Biological activity; Biology and Life Sciences; Cancer; Cancer therapies; Care and treatment; Cyanobacteria; Diagnosis; Disease; Drug development; ESR1 protein; Free energy; Gastric cancer; Genes; Health aspects; Humans; Ingredients; Kinases; Ligands; Medical prognosis; Medicine and Health Sciences; Metabolic pathways; Metabolites; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; Molecular modelling; Mortality; Natural products; Network Pharmacology; Oxidative stress; Pharmacology; Phosphatidylinositol; Physical Sciences; Prevention; Proteins; Sarcoma; Signal Transduction; Software; Solvents; Stat3 protein; Stomach cancer; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism; Stomach Neoplasms - microbiology; Stomach Neoplasms - therapy; Synechococcus; Synechococcus - chemistry; Synechococcus - metabolism; Testing; China

We investigated the potential molecular mechanisms of Synechococcus sp. XM-24 affect gastric cancer (GC) development. Furthermore, this study aimed to provide a theoretical basis for developing novel therapeutic drugs for treating GC. The interactions between Synechococcus sp. XM-24 and targeted pro...