Pathogenesis of systemic lupus erythematosus revisited 2011: End organ resistance to damage, autoantibody initiation and diversification, and HLA-DR

• Published in: Journal of autoimmunity Vol. 37; no. 2; pp. 104 - 112
• Main Authors: Fu, Shu Man, Deshmukh, Umesh S., Gaskin, Felicia
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.09.2011; Elsevier
• Subjects: Allergy and Immunology; Animals; Antibody Diversity; Autoantibodies - genetics; Autoantibodies - immunology; B-Lymphocytes - immunology; Biological and medical sciences; Cross-reactive T and B cell epitopes; Epitope spreading; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene-Environment Interaction; Genetic Predisposition to Disease; History, 20th Century; History, 21st Century; HLA-D and end organ damage; HLA-DR Antigens - genetics; HLA-DR Antigens - immunology; Humans; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - history; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - physiopathology; Medical sciences; Models, Immunological; Multiple Organ Failure; Pathogenesis; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Systemic lupus erythematosus; T-Lymphocytes - immunology; Cross-reactive T and B cell epitopes; Epitope spreading; Systemic lupus erythematosus; Pathogenesis; HLA-D and end organ damage; Autoimmunity; HLA-System; Skin disease; Antigenic determinant; Class II histocompatibility antigen; Autoimmune disease; HLA-DR-Locus; Immunology; Systemic disease; T-Lymphocyte; Cross reaction; Initiation; Immunopathology; Connective tissue disease; Antibody; Autoantibody; B-Lymphocyte; Diversification; Resistance; Lesion; Organ

Systemic lupus erythematosus (SLE) is a multi-system disorder resulting from interaction of susceptibility genes and environmental factors. SLE has protean clinical presentations at the initial diagnosis and relapses. SLE-related autoantibodies have unique patterns of diversification to linked prote...