Identifying producers of antibacterial compounds by screening for antibiotic resistance

• Published in: Nature biotechnology Vol. 31; no. 10; pp. 922 - 927
• Main Authors: Thaker, Maulik N, Wang, Wenliang, Spanogiannopoulos, Peter, Waglechner, Nicholas, King, Andrew M, Medina, Ricardo, Wright, Gerard D
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2013; Nature Publishing Group
• Subjects: 631/154/1435; 631/154/349; Actinobacteria - chemistry; Actinobacteria - drug effects; Agriculture; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibacterial materials; Antibiotic resistance; Antibiotics; Antimicrobial agents; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biosynthesis; Biosynthetic Pathways - drug effects; Biotechnology; Drug Evaluation, Preclinical - methods; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Microbial - drug effects; Glycopeptides; Glycopeptides - biosynthesis; Glycopeptides - chemistry; Glycopeptides - isolation & purification; Glycopeptides - pharmacology; Life Sciences; Microbiology; Microorganisms; Natural products; Peptides; Phylogeny; Properties; Reproducibility of Results; Rifampin - chemistry; Rifampin - pharmacology; Scaffolds; Screening; Synthetic biology; Vancomycin - chemistry; Vancomycin - isolation & purification; Vancomycin - pharmacology; United States

Selecting for microorganisms resistant to known antibiotics enables discovery of strains that produce structurally related compounds. Microbially derived natural products are major sources of antibiotics and other medicines, but discovering new antibiotic scaffolds and increasing the chemical divers...