Non-invasive early detection of cancer four years before conventional diagnosis using a blood test
Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long...
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| Published in | Nature communications Vol. 11; no. 1; pp. 3475 - 10 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
21.07.2020
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80–93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93–98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89–98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care.
Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients. |
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| AbstractList | Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80-93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93-98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89-98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care.Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80-93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93-98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89-98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care. Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients. Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80–93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93–98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89–98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care. Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients. Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80–93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93–98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89–98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care.Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients. Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80-93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93-98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89-98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care. |
| ArticleNumber | 3475 |
| Author | Gore, Athurva Wang, Jiucun Chen, Xingdong McConnell, Catie Zhang, Xiang Zhang, Tiejun Liu, Rui Zhang, Juan Fan, Min Yu, Shunzhang Niu, Hongyu Yuan, Ziyu Jin, Li Lu, Ming Shi, Han Min, Jun Li, Zhe Xie, Zhen Suo, Chen Cheng, Lei Dang, Justin Ye, Weimin Gao, Yuan Yang, Yajun Zhang, Zhenhua Gole, Jeffrey Zhang, Kun He, Qiye Jiang, Yanfeng Wang, Xiaofeng Yang, Xiaorong Li, Xiaojie |
| Author_xml | – sequence: 1 givenname: Xingdong surname: Chen fullname: Chen, Xingdong organization: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Taizhou Institute of Health Sciences, Fudan University, Human Phenome Institute, Fudan University – sequence: 2 givenname: Jeffrey surname: Gole fullname: Gole, Jeffrey organization: Singlera Genomics Inc – sequence: 3 givenname: Athurva surname: Gore fullname: Gore, Athurva organization: Singlera Genomics Inc – sequence: 4 givenname: Qiye surname: He fullname: He, Qiye organization: Singlera Genomics (Shanghai) Ltd – sequence: 5 givenname: Ming surname: Lu fullname: Lu, Ming organization: Taizhou Institute of Health Sciences, Fudan University, Clinical Epidemiology Unit, Qilu Hospital of Shandong University – sequence: 6 givenname: Jun surname: Min fullname: Min, Jun organization: Singlera Genomics Inc – sequence: 7 givenname: Ziyu surname: Yuan fullname: Yuan, Ziyu organization: Taizhou Institute of Health Sciences, Fudan University – sequence: 8 givenname: Xiaorong surname: Yang fullname: Yang, Xiaorong organization: Taizhou Institute of Health Sciences, Fudan University, Clinical Epidemiology Unit, Qilu Hospital of Shandong University – sequence: 9 givenname: Yanfeng surname: Jiang fullname: Jiang, Yanfeng organization: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Taizhou Institute of Health Sciences, Fudan University – sequence: 10 givenname: Tiejun surname: Zhang fullname: Zhang, Tiejun organization: Department of Epidemiology, School of Public Health, Fudan University – sequence: 11 givenname: Chen surname: Suo fullname: Suo, Chen organization: Department of Epidemiology, School of Public Health, Fudan University – sequence: 12 givenname: Xiaojie surname: Li fullname: Li, Xiaojie organization: Singlera Genomics (Shanghai) Ltd – sequence: 13 givenname: Lei surname: Cheng fullname: Cheng, Lei organization: Singlera Genomics (Shanghai) Ltd – sequence: 14 givenname: Zhenhua surname: Zhang fullname: Zhang, Zhenhua organization: Singlera Genomics (Shanghai) Ltd – sequence: 15 givenname: Hongyu surname: Niu fullname: Niu, Hongyu organization: Singlera Genomics (Shanghai) Ltd – sequence: 16 givenname: Zhe surname: Li fullname: Li, Zhe organization: Singlera Genomics (Shanghai) Ltd – sequence: 17 givenname: Zhen surname: Xie fullname: Xie, Zhen organization: Singlera Genomics (Shanghai) Ltd – sequence: 18 givenname: Han surname: Shi fullname: Shi, Han organization: Singlera Genomics Inc – sequence: 19 givenname: Xiang surname: Zhang fullname: Zhang, Xiang organization: Taizhou Disease Control and Prevention Center – sequence: 20 givenname: Min surname: Fan fullname: Fan, Min organization: Taixing Disease Control and Prevention Center – sequence: 21 givenname: Xiaofeng surname: Wang fullname: Wang, Xiaofeng organization: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Taizhou Institute of Health Sciences, Fudan University – sequence: 22 givenname: Yajun surname: Yang fullname: Yang, Yajun organization: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Taizhou Institute of Health Sciences, Fudan University – sequence: 23 givenname: Justin surname: Dang fullname: Dang, Justin organization: Singlera Genomics Inc – sequence: 24 givenname: Catie surname: McConnell fullname: McConnell, Catie organization: Singlera Genomics Inc – sequence: 25 givenname: Juan surname: Zhang fullname: Zhang, Juan organization: Taizhou Institute of Health Sciences, Fudan University – sequence: 26 givenname: Jiucun surname: Wang fullname: Wang, Jiucun organization: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Taizhou Institute of Health Sciences, Fudan University, Human Phenome Institute, Fudan University – sequence: 27 givenname: Shunzhang surname: Yu fullname: Yu, Shunzhang organization: Taizhou Institute of Health Sciences, Fudan University, Department of Epidemiology, School of Public Health, Fudan University – sequence: 28 givenname: Weimin surname: Ye fullname: Ye, Weimin email: weimin.ye@ki.se organization: Taizhou Institute of Health Sciences, Fudan University, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet – sequence: 29 givenname: Yuan surname: Gao fullname: Gao, Yuan email: gary.gao@singleragenomics.com organization: Singlera Genomics Inc – sequence: 30 givenname: Kun orcidid: 0000-0002-7596-5224 surname: Zhang fullname: Zhang, Kun email: kzhang@bioeng.ucsd.edu organization: Department of Bioengineering, University of California at San Diego – sequence: 31 givenname: Rui surname: Liu fullname: Liu, Rui email: rliu@singleragenomics.com organization: Singlera Genomics Inc., Singlera Genomics (Shanghai) Ltd – sequence: 32 givenname: Li surname: Jin fullname: Jin, Li email: lijin@fudan.edu.cn organization: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Taizhou Institute of Health Sciences, Fudan University, Human Phenome Institute, Fudan University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32694610$$D View this record in MEDLINE/PubMed |
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| Snippet | Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before... Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating... |
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| Title | Non-invasive early detection of cancer four years before conventional diagnosis using a blood test |
| URI | https://link.springer.com/article/10.1038/s41467-020-17316-z https://www.ncbi.nlm.nih.gov/pubmed/32694610 https://www.proquest.com/docview/2425726415 https://www.proquest.com/docview/2426177637 https://pubmed.ncbi.nlm.nih.gov/PMC7374162 https://doaj.org/article/f13abdef111b44f5aeede14fcb526903 |
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