1758-P: Alterations in Human Visceral Adipose Tissue Type 2 Innate Lymphoid Cells (ILC2s) with Aging: A Determinant of Insulin Resistance

• Published in: Diabetes (New York, N.Y.) Vol. 68; no. Supplement_1
• Main Authors: BRADLEY, DAVID, BLASZCZAK, ALECIA M., LIU, JOEY Z., JALILVAND, ANAHITA D., WRIGHT, VALERIE P., NORIA, SABRENA, JOSEPH, JOSHUA, HSUEH, WILLA
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2019
• Subjects: Adipocytes; Adipose tissue; Aging; Beta cells; Body weight; Body weight loss; Flow cytometry; Glucose; High fat diet; Homeostasis; Hyperinsulinemia; Insulin; Insulin resistance; Lymphoid cells; Metabolism; Obesity; Surgery; Therapeutic applications

Background: The obese adipose tissue (AT) immune cell microenvironment contributes to low-grade inflammation increasing the risk of multiple metabolic complications. Type 2 innate lymphoid cells (ILC2s) were recently discovered in mice to regulate metabolic health, but the clinical relevance of ILC2...