Regulation of the perilymphatic–endolymphatic water shunt in the cochlea by membrane translocation of aquaporin-5

• Published in: Pflügers Archiv Vol. 467; no. 12; pp. 2571 - 2588
• Main Authors: Eckhard, A., Dos Santos, A., Liu, W., Bassiouni, M., Arnold, H., Gleiser, C., Hirt, B., Harteneck, C., Müller, M., Rask-Andersen, H., Löwenheim, H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2015; Springer Nature B.V
• Subjects: Animals; Aquaporin 4 - genetics; Aquaporin 4 - metabolism; Aquaporin 5 - genetics; Aquaporin 5 - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell Membrane - metabolism; Cholinergic Agents - pharmacology; Cochlea - drug effects; Cochlea - metabolism; Endolymph - metabolism; Homeostasis; Human Physiology; Humans; Mice; Molecular Medicine; Neurosciences; Receptor, Muscarinic M3 - agonists; Receptor, Muscarinic M3 - antagonists & inhibitors; Receptor, Muscarinic M3 - metabolism; Receptors; Sensory Physiology; Water - metabolism; Cochlea; Pilocarpine; Muscarinic; Ménière’s disease; Aquaporin; Water permeability

Volume homeostasis of the cochlear endolymph depends on radial and longitudinal endolymph movements (LEMs). LEMs measured in vivo have been exclusively recognized under physiologically challenging conditions, such as experimentally induced alterations of perilymph osmolarity or endolymph volume. The...