Genomics and transcriptomics of the green mussel explain the durability of its byssus

Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which...

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Published inScientific reports Vol. 11; no. 1; pp. 5992 - 11
Main Authors Inoue, Koji, Yoshioka, Yuki, Tanaka, Hiroyuki, Kinjo, Azusa, Sassa, Mieko, Ueda, Ikuo, Shinzato, Chuya, Toyoda, Atsushi, Itoh, Takehiko
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.03.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/443
631/45
Animals
Computational Biology - methods
Gene Expression Profiling - methods
Gene Expression Regulation
Genome
Genomics - methods
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Lectins
Lysozyme
Marine ecosystems
Molecular Sequence Annotation
Mollusks
multidisciplinary
Perna - classification
Perna - genetics
Perna - physiology
Phylogeny
Proteinase
Proteinase inhibitors
Proteins
Proteins - metabolism
Science
Science (multidisciplinary)
Structural proteins
Transcriptome
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Abstract Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which it achieves such durability are unknown. Here we report comprehensive identification of genes involved in byssus formation through whole-genome and foot-specific transcriptomic analyses of the green mussel, Perna viridis . Interestingly, proteins encoded by highly expressed genes include proteinase inhibitors and defense proteins, including lysozyme and lectins, in addition to structural proteins and protein modification enzymes that probably catalyze polymerization and insolubilization. This assemblage of structural and protective molecules constitutes a multi-pronged strategy to render the byssus highly resistant to environmental insults.
AbstractList Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which it achieves such durability are unknown. Here we report comprehensive identification of genes involved in byssus formation through whole-genome and foot-specific transcriptomic analyses of the green mussel, Perna viridis . Interestingly, proteins encoded by highly expressed genes include proteinase inhibitors and defense proteins, including lysozyme and lectins, in addition to structural proteins and protein modification enzymes that probably catalyze polymerization and insolubilization. This assemblage of structural and protective molecules constitutes a multi-pronged strategy to render the byssus highly resistant to environmental insults.
Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which it achieves such durability are unknown. Here we report comprehensive identification of genes involved in byssus formation through whole-genome and foot-specific transcriptomic analyses of the green mussel, Perna viridis. Interestingly, proteins encoded by highly expressed genes include proteinase inhibitors and defense proteins, including lysozyme and lectins, in addition to structural proteins and protein modification enzymes that probably catalyze polymerization and insolubilization. This assemblage of structural and protective molecules constitutes a multi-pronged strategy to render the byssus highly resistant to environmental insults.
Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which it achieves such durability are unknown. Here we report comprehensive identification of genes involved in byssus formation through whole-genome and foot-specific transcriptomic analyses of the green mussel, Perna viridis. Interestingly, proteins encoded by highly expressed genes include proteinase inhibitors and defense proteins, including lysozyme and lectins, in addition to structural proteins and protein modification enzymes that probably catalyze polymerization and insolubilization. This assemblage of structural and protective molecules constitutes a multi-pronged strategy to render the byssus highly resistant to environmental insults.Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which it achieves such durability are unknown. Here we report comprehensive identification of genes involved in byssus formation through whole-genome and foot-specific transcriptomic analyses of the green mussel, Perna viridis. Interestingly, proteins encoded by highly expressed genes include proteinase inhibitors and defense proteins, including lysozyme and lectins, in addition to structural proteins and protein modification enzymes that probably catalyze polymerization and insolubilization. This assemblage of structural and protective molecules constitutes a multi-pronged strategy to render the byssus highly resistant to environmental insults.
Abstract Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus, which is tough, durable, and resistant to enzymatic degradation. Although various byssal proteins have been identified, the mechanisms by which it achieves such durability are unknown. Here we report comprehensive identification of genes involved in byssus formation through whole-genome and foot-specific transcriptomic analyses of the green mussel, Perna viridis. Interestingly, proteins encoded by highly expressed genes include proteinase inhibitors and defense proteins, including lysozyme and lectins, in addition to structural proteins and protein modification enzymes that probably catalyze polymerization and insolubilization. This assemblage of structural and protective molecules constitutes a multi-pronged strategy to render the byssus highly resistant to environmental insults.
ArticleNumber 5992
Author Ueda, Ikuo
Tanaka, Hiroyuki
Kinjo, Azusa
Itoh, Takehiko
Shinzato, Chuya
Inoue, Koji
Yoshioka, Yuki
Toyoda, Atsushi
Sassa, Mieko
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  organization: Department of Biological Information, Tokyo Institute of Technology
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  organization: Atmosphere and Ocean Research Institute, The University of Tokyo
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  surname: Itoh
  fullname: Itoh, Takehiko
  organization: Department of Biological Information, Tokyo Institute of Technology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33727571$$D View this record in MEDLINE/PubMed
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Snippet Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the byssus,...
Abstract Mussels, which occupy important positions in marine ecosystems, attach tightly to underwater substrates using a proteinaceous holdfast known as the...
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SubjectTerms 631/443
631/45
Animals
Computational Biology - methods
Gene Expression Profiling - methods
Gene Expression Regulation
Genome
Genomics - methods
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Lectins
Lysozyme
Marine ecosystems
Molecular Sequence Annotation
Mollusks
multidisciplinary
Perna - classification
Perna - genetics
Perna - physiology
Phylogeny
Proteinase
Proteinase inhibitors
Proteins
Proteins - metabolism
Science
Science (multidisciplinary)
Structural proteins
Transcriptome
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Title Genomics and transcriptomics of the green mussel explain the durability of its byssus
URI https://link.springer.com/article/10.1038/s41598-021-84948-6
https://www.ncbi.nlm.nih.gov/pubmed/33727571
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https://doaj.org/article/6fed99ff34d442bd8e5ab64743dd2e78
Volume 11
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