Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

• Published in: Diabetes (New York, N.Y.) Vol. 58; no. 5; pp. 1229 - 1236
• Main Authors: Brasacchio, Daniella, Okabe, Jun, Tikellis, Christos, Balcerczyk, Aneta, George, Prince, Baker, Emma K., Calkin, Anna C., Brownlee, Michael, Cooper, Mark E., El-Osta, Assam
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2009
• Subjects: Amino acids; Animals; Biological and medical sciences; Cattle; Complications and side effects; Diabetes; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - genetics; DNA binding proteins; DNA Methylation; DNA Primers; DNA, Complementary - genetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - physiology; Enzymes; Epidemiology; Epigenetics; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Genetic aspects; Genetic Predisposition to Disease; Genetic transcription; Glucose; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - enzymology; Hyperglycemia - genetics; Hyperglycemia - pathology; Lysine - metabolism; Medical sciences; Methyltransferases; Original; Peptides; Physiological aspects; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA - genetics; RNA - isolation & purification; Transcription (Genetics); United States; United Kingdom > UK; Endocrinopathy; Hyperglycemia; Gene; Enzyme; Lysine; Aminoacid; Diabetes mellitus; Tail; Epigenetics; Histone

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail Daniella Brasacchio 1 , Jun Okabe 1 , Christos Tikellis 2 , Aneta Balcerczyk 1 , Prince George 1 , Emma K. Baker 1 , Anna C. Cal...