Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail - Brasacchio, Daniella; Okabe, Jun; Tikellis, Christos; Balcerczyk, Aneta; George, Prince; Baker, Emma K.; Calkin, Anna C.; Brownlee, Michael; Cooper, Mark E.; El-Osta, Assam (Diabetes (New York, N.Y.), 2009)
Keywords: Amino acids; Animals; Biological and medical sciences; Cattle; Complications and side effects; Diabetes; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - genetics; DNA binding proteins; DNA Methylation; DNA Primers; DNA, Complementary - genetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - physiology; Enzymes; Epidemiology; Epigenetics; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Genetic aspects; Genetic Predisposition to Disease; Genetic transcription; Glucose; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - enzymology; Hyperglycemia - genetics; Hyperglycemia - pathology; Lysine - metabolism; Medical sciences; Methyltransferases; Original; Peptides; Physiological aspects; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA - genetics; RNA - isolation & purification; Transcription (Genetics); United States; United Kingdom--UK; Endocrinopathy; Hyperglycemia; Gene; Enzyme; Lysine; Aminoacid; Diabetes mellitus; Tail; Epigenetics; Histone