Effect of ovary lipid from Skipjack Tuna (Katsuwonus pelamis) on brain monoamines in rats

• Published in: Journal of Veterinary Medical Science Vol. 69; no. 6; pp. 593 - 598
• Main Authors: Ookawa, K.(Shizuoka-ken. Industrial Research Inst. (Japan)), Mochizuki, K, Shida, E, Suzuki, T, Ooba, T, Matumoto, T, Hokari, Y, Yokogoshi, H
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.06.2007; Japan Science and Technology Agency
• Subjects: 5-Hydroxy-3-indoleacetic acid; 5-Hydroxytryptamine; AMINAS; AMINE; AMINES; Animals; anxiety and/or fear; BEHAVIOUR; Biogenic Monoamines - metabolism; Brain - drug effects; Brain - metabolism; COMPORTAMIENTO; COMPORTEMENT; ESTRES; Euthynnus pelamis; Female; Hypothalamus - drug effects; Hypothalamus - metabolism; Katsuwonus; KATSUWONUS PELAMIS; LIPIDE; LIPIDOS; LIPIDS; Lipids - pharmacology; Locus Coeruleus - drug effects; Locus Coeruleus - metabolism; Male; Marine; monoamine; OVAIRE; OVARIES; OVARIOS; Ovary - chemistry; ovary lipid; Pelamis; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; RAT; RATA; RATS; SEROTONIN; SEROTONINA; SEROTONINE; STRESS; Thunnus; Tuna
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.69.593

In our previous experiments with rats, ovary lipid from Skipjack Tuna (Katsuwonus pelamis) (OLS) was shown to have a mitigating effect on anxiety and/or fear in elevated T-maze tests. This suggests that OLS has some effect on the central nervous system (CNS) of rats. Thus, we performed experiments to examine the status of CNS in rats given OLS. The effect of OLS on chronic stress was also examined at the same time. The feed for control rats used oil and fat that have the same energy percentages for n-6 and n-3 fatty acids and the same n-6/n-3 ratio as OLS. As a result, rats given OLS for 28 days had lower serotonin levels in various brain areas showing that OLS affected the serotonin nervous system. From this, it was inferred that the ability of regardless of stress application, OLS to mitigate anxiety and/or fear resulted from its action on CNS, especially the serotonin nervous system. Substances other than the essential fatty acids may have been responsible for the action of OLS on monoamines and the metabolites. The effect of OLS on CNS, especially the serotonin nervous system, suggests that OLS may suppress anxiety.