Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis

• Published in: Nature reviews. Immunology Vol. 16; no. 11; pp. 661 - 675
• Main Author: Cadwell, Ken
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2016; Nature Publishing Group
• Subjects: 631/250/2152; 631/250/262; 631/80/82/39; Adaptive Immunity; Amino acids; Animals; Antigen presentation; Autophagosomes - immunology; Autophagosomes - metabolism; Autophagy; Autophagy (Cytology); Autophagy - immunology; Bacteria; Biomedicine; Care and treatment; Cellular signal transduction; Communicable diseases; Cytokines; Defense; Disease Susceptibility; Health aspects; Homeostasis; Homeostasis - immunology; Host-Pathogen Interactions - immunology; Humans; Immune response; Immunity; Immunity, Innate; Immunology; Infections; Inflammation - immunology; Inflammation - metabolism; Inflammatory diseases; Observations; Pathogens; Pattern recognition; Pattern recognition receptors; Proteins; review-article; Signal Transduction; Tumor necrosis factor-TNF; Viruses; New York; United States > US

Key Points The cellular degradative process of autophagy participates in multiple aspects of immunity, including cell-autonomous defence, innate immune signalling and antigen presentation. Extensive crosstalk between autophagy and inflammatory signalling cascades ensures a robust immune response tow...