MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 - Uemura, Kentaro; Sasaki, Michihito; Sanaki, Takao; Toba, Shinsuke; Takahashi, Yoshimasa; Orba, Yasuko; Hall, William W.; Maenaka, Katsumi; Sawa, Hirofumi; Sato, Akihiko (Scientific reports, 2021)
Keywords: 631/326; 631/326/596; 631/326/596/1296; 631/326/596/4130; ACE2; Angiotensin; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Antiviral drugs; Cell Engineering; Cell Line; Coronaviruses; COVID-19; COVID-19 - drug therapy; Drug development; Drug Discovery; Humanities and Social Sciences; Humans; Infectivity; Models, Biological; multidisciplinary; Pandemics; Peptidyl-dipeptidase A; Replication; Ribonucleic acid; RNA; RNA viruses; SARS-CoV-2 - drug effects; SARS-CoV-2 - physiology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Vaccine development; Vero cells; Viral Proteins - biosynthesis; Virus Replication - drug effects