Metabolic engineering of an acid-tolerant yeast strain Pichia kudriavzevii for itaconic acid production

• Published in: Metabolic engineering communications Vol. 10; no. C; p. e00124
• Main Authors: Sun, Wan, Vila-Santa, Ana, Liu, Na, Prozorov, Tanya, Xie, Dongming, Faria, Nuno Torres, Ferreira, Frederico Castelo, Mira, Nuno Pereira, Shao, Zengyi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2020; Elsevier
• Subjects: Acid tolerance; acrylic acid; Aspergillus terreus; BASIC BIOLOGICAL SCIENCES; batch fermentation; beta acids; Biopolymers; CRISPR-Cas systems; culture flasks; cytosol; gene overexpression; genes; hosts; industry; isocitrate dehydrogenase; Issatchenkia orientalis; Itaconic acid; metabolic engineering; mitochondria; Non-conventional microorganisms; pathogenicity; Pichia kudriavzevii; polymerization; Special issue on Non-conventional microbes edited by Ian Wheeldon and Aindrila Mukhopadhyay; yeasts; Itaconic acid; Issatchenkia orientalis; Pichia kudriavzevii; Acid tolerance; Biopolymers; Non-conventional microorganisms

Itaconic acid (IA), or 2-methylenesuccinic acid, has a broad spectrum of applications in the biopolymer industry owing to the presence of one vinyl bond and two acid groups in the structure. Its polymerization can follow a similar mechanism as acrylic acid but additional functionality can be incorpo...